Early treatment and prevention of increased muscle tonicity

Details Early treatment and prevention of increased muscle tonicity Early treatment and prevention of increased muscle tonicity

A - Human Necessities

61

K

A61K 35/74 (2006.01) A61P 25/14 (2006.01)

Patent

CA 2744000

Described herein are methods of preventing, modulating and treating spasticity and maladaptive neuronal plasticity in patients having upper motor neuron lesions or have had a traumatic central nervous system event by early intervention methods. The methods comprise the step of administering a therapeutically effective amount of a botulinum toxin or derivative thereof to least a portion of a 1A sensory afferent of at least one muscle prior to development of spasticity or maladaptive neuronal plasticity becomes clinically apparent. The therapeutically effective amount of botulinum toxin administered to the 1A afferent of the mus-cle does not substantially affect the Golgi tendons therein.

L'invention porte sur des procédés de prévention, modulation et traitement de la spasticité et de la plasticité neuronale inadaptée chez des patients souffrant de lésions de neurones moteurs supérieurs ou qui ont subi un événement traumatique du système nerveux central par des procédés d'intervention précoce. Les procédés comprennent l'étape consistant à administrer une quantité thérapeutiquement efficace d'une toxine botulinique ou d'un dérivé de celle-ci à au moins une partie d'un afférent sensoriel 1A d'au moins un muscle avant que le développement de la spasticité ou de plasticité neuronale inadaptée ne devienne cliniquement apparent. La quantité thérapeutiquement efficace de toxine botulinique administrée à l'afférent 1A du muscle n'affecte pas sensiblement les tendons de Golgi.

Affiliated with

Also associated with

Rating

Early treatment and prevention of increased muscle tonicity does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Early treatment and prevention of increased muscle tonicity, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Early treatment and prevention of increased muscle tonicity will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1570278