Easily split substrates for the quantification of proteases

Details Easily split substrates for the quantification of proteases Easily split substrates for the quantification of proteases

C - Chemistry, Metallurgy

07

K

530/5.08, 150/15

C07K 5/097 (2006.01) C12Q 1/37 (2006.01) C12Q 1/56 (2006.01)

Patent

CA 1136124

A B S T R A C T Easily split enzyme substrates for the quantification of proteases having the general formula R1 - p-Glu - Al - A2 - NH R2, wherein R1 = H or a protective group, preferably t-butyl- oxycarbonyl, benzyloxycarbonyl; Al = Gly, Ala, Val, Leu, Ile, Ser, Thr, Pro, Pip, Phe or Tyr; A2 = Arg or Lys; R2 = an aromatic, possibly substituted, hydrocar- bon group, wherein -NH-R2 is a physico-chemi- cally determinable group, preferably a chromo- genic or fluorogenic group which is split by a present enzyme and then forms a cleavage product of the formula H2N - R2 the amount of which can be quantified. Process for the production of said substrates. Method in the laboratory diagnostics of proteases using said substrates.

320702

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