A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 35/12 (2006.01) A61L 27/36 (2006.01) A61L 27/60 (2006.01)
Patent
CA 2448436
A method of forming and preserving a bioremodelable, biopolymer scaffold material by subjecting animal tissue, particularly fetal or neo-natal tissue, to chemical and mechanical processing. The process includes, but is not limited to, harvesting the tissue, optionally extracting growth and differentiation factors from the tissue, inactivating infective agents of the tissue, mechanically expressing undesirable components from the tissue, delipidizing the tissue, washing the tissue, optionally drying the tissue and optionally cross-linking the tissue not necessarily in the order described. The resulting product, EBM, is characterized by its microbial, fungal, viral and prion inactivated state. EBM is strong, bioremodelable, drapable and does not undergo calcification. EBM supplants previous inventions because of its unique method of preparation and broad applicability in tissue reengineering.
L'invention concerne un procédé relatif à la formation et à la préservation d'un matériau support en biopolymère bioremodelable qui consiste à soumettre du tissu animal, en particulier foetal ou néonatal, à un traitement chimique et mécanique. Il s'agit notamment, mais pas exclusivement, de recueillir le tissu, éventuellement d'en extraire des facteurs de croissance et de différenciation, d'inactiver les agents infectieux du tissu, d'exprimer mécaniquement les composantes indésirables du tissu, d'éliminer les lipides du tissu, de laver le tissu, éventuellement de sécher le tissu, et éventuellement de réticuler le tissu, pas nécessairement dans l'ordre cité. Le produit résultant, appelé matrice EB, a pour caractéristique un état microbien, fongique, viral et prion inactivé. Cette matrice, qui est solide, bioremodelable et moulable, ne subit aucune calcification. Elle est supérieure aux produits inventés précédemment par son élaboration unique et son large éventail d'applications à la réparation tissulaire.
Bell Eugene
Dai Jianwu
Russakovsky Vladimir
Riches Mckenzie & Herbert Llp
Tei Biosciences Inc.
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