C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 7/06 (2006.01) A61K 31/70 (2006.01) A61K 39/245 (2006.01) A61K 39/295 (2006.01) C07K 14/05 (2006.01) A61K 39/00 (2006.01)
Patent
CA 2255927
The present invention provides cytotoxic Epstein-Barr virus T-cell epitopes. These epitopes are QVKWRMTTL, VFSDGRVAC, VPAPAGPIV, TYSAGIVQI, LLDFVRFMGV, QNGALAINTF, VSSDGRVAC, VSSEGRVAC, VSSDGRVPC, VSSDGLVAC, VSSDGQVAC, VSSDGRVVC, VPAPPVGPIV, VEITPYEPTG, VEITPYEPTW, VELTPYKPTW, RRIYDLIKL, RKIYDLIEL and PYLFWLAGI. The present invention further provides vaccines including one or more of these epitopes, optionally with additional epitopes.
Epitopes de lymphocytes T cytotoxiques du virus d'Epstein-Barr. Ces épitopes sont QVKWRMTTL, VFSDGRVAC, VPAPAGPIV, TYSAGIVQI, LLDFVRFMGV, QNGALAINTF, VSSDGRVAC, VSSEGRVAC, VSSDGRVPC, VSSDGLVAC, VSSDGQVAC, VSSDGRVVC, VPAPPVGPIV, VEITPYEPTG, VEITPYEPTW, VELTPYKPTW, RRIYDLIKL, RKIYDLIEL et PYLFWLAGI. L'invention porte en outre sur des vaccins contenant un ou plusieurs de ces épitopes, et en option d'autres épitopes.
Burrows Scott Renton
Kerr Beverley Mavis
Khanna Rajiv
Misko Ihor Stephan
Moss Denis James
Biotech Australia Pty. Limited
Commonwealth Scientific And Industrial Research Organisation
Csl Limited
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
The Council Of The Queensland Institute Of Medical Research
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