A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/12 (2006.01) A61K 9/107 (2006.01) A61K 9/19 (2006.01) A61K 31/407 (2006.01) A61K 38/08 (2006.01) A61K 47/06 (2006.01) A61K 47/22 (2006.01) A61P 31/10 (2006.01) C07K 7/56 (2006.01)
Patent
CA 2362481
Pharmaceutical formulations are described comprising an echinocandin compound or echinocandin/carbohydrate complex and a pharmaceutically acceptable micelle-forming surfactant in a non-toxic aqueous solvent such that the solubilization of the echinocandin compound is optimized and the ability to freeze-dry the solution is maintained. Both the solution and freeze-dried formulations have increased stability. A bulking agent, tonicity agent buffer and/or a stabilizing agent may optionally be added to the formulations to further enhance the stability of the formulation.
L'invention concerne des formulations pharmaceutiques comprenant un composé d'échinocandine ou un complexe d'échinocandine/hydrate de carbone, et un tensioactif formant une micelle pharmaceutiquement acceptable dans un solvant non toxique aqueux, de sorte que la solubilité du composé d'échinocandine est optimisée, et sa capacité de lyophilisation est maintenue. La stabilité de la solution et des formulations lyophilisées est augmentée. Un agent gonflant, un tampon et/ou un agent de stabilisation peuvent éventuellement être ajoutés aux formulations, de façon à améliorer ultérieurement la stabilité de ladite formulation.
Milton Nathaniel
Moder Kenneth Philip
Sabatowski James Lawrence
Sweetana Stephanie Ann
Borden Ladner Gervais Llp
Eli Lilly And Company
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