C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A61K 38/17 (2006.01) A61K 39/395 (2006.01) A61P 35/00 (2006.01) C07K 14/78 (2006.01) C07K 16/18 (2006.01) C12Q 1/68 (2006.01) G01N 33/53 (2006.01) G01N 33/574 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2413158
The invention provides a cDNA which encodes a ECM-related protein. It also provides for the use of the cDNA, fragments, complements, and variants thereof and of the encoded protein, portions thereof and antibodies thereto for diagnosis and treatment of disorders, particularly colon and lung cancer. The invention additionally provides expression vectors and host cells for the production of the protein and a transgenic model system.
L'invention porte sur un ADNc qui code une protéine associée à la matrice extracellulaire, et également sur l'utilisation de l'ADNc, de fragments, compléments et variants de celui-ci et de la protéine codée, des parties de celle-ci et des anticorps dans le développement et le traitement de pathologies, notamment le cancer du côlon et des poumons. L'invention porte également sur des vecteurs d'expression et des cellules hôtes utilisés dans la production de la protéine et sur un système de modèle transgénique.
Arvizu Chandra S.
Lasek Amy K. W.
Yue Henry
Arvizu Chandra S.
Incyte Genomics Inc.
Lasek Amy K. W.
Smart & Biggar
Yue Henry
LandOfFree
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