Ectoparasiticidal aqueous suspension formulations of spinosyns

A - Human Necessities – 61 – K

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Details

A61K 31/7048 (2006.01) A61K 9/107 (2006.01) A61P 33/14 (2006.01)

Patent

CA 2379331

The invention provides a stable ectoparasiticidal aqueous suspension formulation of a spinosyn, comprising the spinosyn, or a physiologically acceptable derivative or salt thereof, milled to an average particle size of 1 to 15 microns, a surfactant in an amount effective to facilitate wetting the milled particles; a dispersant in an amount that forms a spinosyn:dispersant weight ration of from 3:1 to 1:5; and water. It also provides a method of controlling an ectoparasite infestation on a small ruminant or companion animal comprising administering an effective amount of such an aqueous suspension formulation.

L'invention concerne une formulation de spinosyne ectoparasiticide stable sous forme de suspension aqueuse comprenant une spinosyne ou un dérivé physiologiquement acceptable ou son sel. La granulométrie de la spinosyne après broyage est comprise entre 1 et 15 microns. La formulation comprend aussi un tensioactif en quantité efficace pour faciliter l'humidification des particules broyées, un dispersant en quantité suffisante pour former un rapport pondéral de spinosyne: dispersant allant de 3:1 à 1:5 et de l'eau. L'invention concerne aussi un procédé permettant de lutter contre l'infestation par ectoparasite d'un animal ruminant ou de compagnie et consistant à administrer une quantité efficace d'une formulation aqueuse.

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