Edible vaccine

A - Human Necessities – 61 – K

Patent

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Details

A61K 39/23 (2006.01) A61K 9/19 (2006.01) A61K 36/06 (2006.01)

Patent

CA 2579882

It is intended to provide an oral vaccine which is efficacious against type 16 human papilloma virus (HPV) and can be supplied on a mass scale at a low cost. Namely, a human papilloma virus vaccine for oral administration comprising a transformant holding an expressed antigen protein of human HPV16 accumulated in its cell which is obtained by transferring a gene encoding this protein into a nonpathogenic fission yeast (Schizosaccharomyces pombe) host and culturing the resultant transformant.

La présente invention a pour objet un vaccin oral qui agit de façon efficace contre le virus du papillome humain (VPH) de type 16, et qui peut être produit à très grande échelle à un coût réduit. Dans un mode préféré de l'invention, le vaccin pour administration orale contre le virus du papillome humain ci-décrit inclut un transformant, dans les cellules duquel est accumulée une protéine antigénique exprimée du VPH 16 humain. Ledit transformant est obtenu en transférant un gène codant pour ladite protéine dans un hôte constitué par une levure de fission non pathogène (<i

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