Educated nk t cells and their uses in the treatment of...

Details Educated nk t cells and their uses in the treatment of... Educated nk t cells and their uses in the treatment of...

A - Human Necessities

61

K

A61K 38/19 (2006.01) A61K 35/14 (2006.01)

Patent

CA 2436501

The present invention relates to a method for the treatment of immune-related disorders in a mammalian subject in need of such treatment. This method comprises the step of manipulating the NK T cell population in said subject by suitable means, said manipulation of the NK T cell population resulting in modulation of the Th1/Th2 balance toward anti-inflammatory cytokine producing cells. Manipulation of the NK T cell population may be performed either by depletion of said cells by a suitable means or alternatively by ex vivo education of the NK T cells, such that the educated NK T cells have the capability to modulate the Th1/Th2 balance toward anti-inflammatory cytokine producing cells. The invention further relates to pharmaceutical compositions for the treatment of immune-related disorders in a mammalian subject. These compositions comprising as an effective ingredient an ex vivo educated NK T cell. The invention further provides for an ex vivo educated NK T cell and uses thereof in the treatment of immune-related disorders.

La présente invention concerne un procédé permettant de traiter des troubles liés à l'immunité chez un sujet mammifère qui a besoin d'un tel traitement. Le procédé précité consiste à manipuler par un moyen adéquat une population de lymphocytes NK chez le sujet précité, la manipulation effectuée entraînant une modulation de l'équilibre Th1/Th2 en faveur des cellules productrices de cytokine anti-inflammatoire. La manipulation de la population de lymphocytes NK peut s'effectuer soit par la déplétion desdites cellules à l'aide d'un moyen adéquat soit, dans un autre mode de réalisation, par l'éducation ex vivo des lymphocytes NK de façon que les lymphocytes NK éduqués deviennent capables de moduler l'équilibre Th1/Th2 en faveur des cellules productrices de cytokine anti-inflammatoire. L'invention concerne également des compositions pharmaceutiques destinées au traitement de troubles liés à l'immunité chez un mammifère. Les compositions précitées comprennent, comme ingrédient actif, un lymphocyte NK éduqué. L'invention se rapporte enfin à un lymphocyte NK éduqué ex vivo et aux utilisations de ce dernier dans le traitement de troubles liés à l'immunité.

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