Educated nkt cells and their uses in the treatment of...

A - Human Necessities – 61 – K

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Details

A61K 39/395 (2006.01) A61K 35/12 (2006.01) A61K 35/28 (2006.01) A61K 35/407 (2006.01) A61P 37/00 (2006.01)

Patent

CA 2540672

The present invention relates to a method for the treatment of immune-related or immune-mediated disorders in a mammalian subject in need of such treatment. This method comprises the step of manipulating the NKT cell population in said subject by suitable means, said manipulation of the NKT cell population resulting in modulation of the Th1/Th2 balance toward anti-inflammatory cytokine producing cells. Manipulation of the NKT cell population may be performed either by depletion of said cells by a suitable means or alternatively by ex vivo education of the NKT cells, such that the educated NKT cells have the capability to modulate the Th1/Th2 balance toward anti- inflammatory cytokine producing cells. The invention further relates to pharmaceutical compositions for the treatment of immune-related or immune- mediated disorders in a mammalian subject. These compositions comprising as an effective ingredient an ex vivo educated NKT cell. The invention further provides for an ex vivo educated NKT cell and uses thereof in the treatment of immune-related or immune-mediated disorders.

La présente invention a trait à un procédé pour le traitement de troubles à association immunitaire ou à médiation immunitaire chez un sujet mammalien nécessitant un tel traitement. Ce procédé comprend l'étape de manipulation de la population de cellules NKT chez ledit sujet par des moyens appropriés, ladite manipulation de la population de cellules NKT entraînant la modulation de l'équilibre Th1/Th2 vers des cellules de production de cytokines anti-inflammatoires. La manipulation de la population des cellules NKT peut être réalisée soit par déplétion desdites cellules par un moyen approprié soit par l'entraînement ex vivo des cellules NKT, de sorte que les cellules NKT entraînées présentent la capacité de moduler l'équilibre Th1/Th2 vers des cellules de production de cytokines anti-inflammatoires. L'invention a également trait à des compositions pharmaceutiques pour le traitement de troubles à association immunitaire ou à médiation immunitaire chez un sujet mammalien. Ces compositions comprennent en tant que principe actif une cellule NKT entraînée ex vivo. L'invention a trait en outre à une cellule NKT entraînée ex vivo et ses utilisations dans le traitement de troubles à association immunitaire ou à médiation immunitaire.

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