A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/17 (2006.01) A61P 25/28 (2006.01) C12Q 1/37 (2006.01) G01N 33/567 (2006.01) C07K 14/705 (2006.01) C12Q 1/68 (2006.01)
Patent
CA 2655048
Provided are methods for reducing inhibiting or preventing A.beta. and/or AID production by a cell and methods of treating a subject having Alzheimer's disease. Also provided are methods of determining whether a compound is a mimic of a BRI2 or a BRI3. Additionally provided are pharmaceutical compositions of BRI2, BRI3 or furin, or vectors encoding those proteins.
L'invention concerne des procédés permettant de réduire l'inhibition ou la prévention de la production de A.beta. et/ou du AID par une cellule, ainsi que des procédés de traitement d'un patient atteint de la maladie d'Alzheimer. L'invention concerne également des procédés de détermination si un composé est ou non un analogue d'une BRI2 ou BRI3. Elle concerne enfin des compositions pharmaceutiques de BRI2 et BRI3 ou de la furine, ou des vecteurs codant ces protéines.
D'adamio Luciano
Matsuda Shuji
Albert Einstein College Of Medicine Of Yeshiva University
Osler Hoskin & Harcourt Llp
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