Effective treatment of tumors and cancer with triciribine...

A - Human Necessities – 61 – K

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A61K 31/7064 (2006.01) A61P 35/00 (2006.01) C07H 19/23 (2006.01)

Patent

CA 2561513

The inventors have determined, contrary to the prior art and experience, how to successfully use triciribine to treat tumors and cancer by one or a combination of (i) administering triciribine only to patients which according to a diagnostic test described below, exhibit enhanced sensitivity to the drug; (ii) use of a described dosage level that minimizes the toxicity of the drug but yet still exhibits efficacy; or (iii) use of a described dosage regimen that minimizes the toxicity of the drug.

Les inventeurs ont pu établir, contrairement aux connaissances et expériences actuelles, comment utiliser avec succès la triciribine pour traiter des tumeurs et le cancer par la mise en oeuvre d'une étape ou d'une combinaison de plusieurs étapes consistant à : (1) n'administrer la triciribine qu'aux patients présentant, selon le test diagnostique décrit, une sensibilité accrue au médicament ; (2) utiliser un dosage décrit qui réduit au minimum la toxicité du médicament tout en étant efficace ; ou (3) utiliser un régime posologique qui réduit au minimum la toxicité du médicament.

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