C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A61K 31/70 (2006.01) A61K 48/00 (2006.01) C07H 21/00 (2006.01) C07K 14/705 (2006.01) C12N 9/12 (2006.01) C12N 9/90 (2006.01) G01N 33/566 (2006.01) G01N 33/68 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2144223
This invention comprises novel Rapamycin-FKBP12 binding proteins of mammalian origin for identification, design and synthesis of immunomodulatory, anti--restenosis or anti-tumor agents, as well as fragments of the proteins and the DNA, cDNA, antisense RNA and DNA segments corresponding to the proteins. This invention also comprises methods for isolating the proteins and therapeutic uses related to the proteins.
La présente invention porte sur de nouvelles protéines de liaison Rapamycine-FKBP12 d'origine mammalienne pour l'identification, la conception et la synthèse d'agents immunomodulateurs, anti-resténosiques ou antitumoraux, ainsi que des fragments des protéines et les segments d'ADN, d'ADNc, d'ARN et d'ADN antisens correspondant aux protéines. Cette invention comprend également des méthodes d'isolation de protéines et des utilisations thérapeutiques liées aux protéines.
Caggiano Thomas Joseph
Chen Yanqiu
Failli Amedeo Arturo
Molnar-Kimber Katherine Lu
Nakanishi Koji
American Home Products Corporation
Ridout & Maybee Llp
The Trustees Of Columbia University
The Trustees Of Columbia University In The City Of New York
Wyeth
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