Effervescent base

Details Effervescent base Effervescent base

A - Human Necessities

61

K

A61K 9/00 (2006.01) A61K 9/46 (2006.01) A61K 31/341 (2006.01) A61K 31/426 (2006.01) A61P 1/04 (2006.01)

Patent

CA 2306633

The effervescent base for the preparation of effervescent tablets and effervescent granules consists of at least one acidic and one gas-evolving component, the former of which is formed by a mixture of (predominantly) monosodium tartrate and (possibly) disodium tartrate, and optionally tartaric acid. The effervescent base is prepared by mixing tartaric acid with sodium bicarbonate and sodium carbonate containing water of crystallization and slowly reacting the mixture at a temperature increasing to about 50 ~C, after which further sodium carbonate containing water of crystallization is admixed and is allowed to react up to a temperature of about 60 ~C, and drying is then carried out, preferably in vacuo, the mixture is mixed with further, now anhydrous sodium carbonate and the product is optionally pressed to give tablets. The base may additionally comprise an acid sensitive or an alkali- sensitive pharmaceutically active substance.

L'invention porte sur une base effervescente servant à la préparation de comprimés et granulés effervescents et consistant en au moins un composé acide ou gazogène, dont le premier est un mélange de tartrate de monosodium (prédominant), de tartrate de disodium (facultatif), et d'acide tartrique. La base effervescente se prépare en mélangeant l'acide tartrique à du bicarbonate de soude et du carbonate de sodium contenant de l'eau de cristallisation, puis en faisant réagir lentement le mélange à une température montant jusqu'à environ 50 ·C, après quoi on rajoute du carbonate de sodium contenant de l'eau de cristallisation et la température de réaction est portée à 60 ·C. On procède ensuite à une dessiccation, de préférence sous vide, puis le mélange est à nouveau mélangé à du carbonate de sodium anhydre, puis le produit résultant est éventuellement pressé pour former des comprimés. La susdite base peut comporter l' adjonction d'une substance à activité pharmacologique réagissant à un acide ou à une base.

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