Effervescent drug delivery system for oral administration

Details Effervescent drug delivery system for oral administration Effervescent drug delivery system for oral administration

A - Human Necessities

61

K

A61K 9/32 (2006.01) A61K 9/36 (2006.01) A61K 9/46 (2006.01) A61K 31/165 (2006.01) A61K 31/525 (2006.01) A61K 9/20 (2006.01) A61K 9/28 (2006.01)

Patent

CA 2335566

The pharmaceutical compositions of the present invention comprise orally administerable dosage forms that use effervescence as a penetration enhancer for drugs known, or suspected, of having poor bioavailability. Effervescence can occur in the stomach, once the tablet or other dosage form is ingested. In addition to effervescence in the stomach, or as alternative technique, by the use of appropriate coatings and other techniques, the effervescence can occur in other parts of the gastrointestinal tract, including, but not limited to, the esophagus, duodenum, and colon. The site of effervescence and drug release is chosen to correspond with the segment of the gastrointestinal tract displaying maximal absorption of the formulated drug, or to gain some other therapeutic advantage.

L'invention concerne des compositions pharmaceutiques comprenant des formes de dosages pouvant être administrées par voie orale ayant recours à l'effervescence pour renforcer la pénétration des médicaments à faible biodisponibilité (ou ceux qui sont supposés l'être). L'effervescence peut se produire dans l'estomac, une fois que le comprimé ou tout autre forme de dosage est ingéré(e). En plus, grâce à des enrobages appropriés et à d'autres techniques, l'effervescence peut avoir lieu à d'autres endroits du tractus gastro-intestinal, à savoir dans l'oesophage, le duodénum et le colon entre autres. Le site de l'effervescence et de la libération du médicament doit correspondre à la partie du tractus gastro-intestinal faisant preuve de la meilleure absorption du médicament préparé ou présenter un autre avantage d'ordre thérapeutique.

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