A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 9/16 (2006.01) A61K 9/46 (2006.01) A61K 33/10 (2006.01) A61K 33/16 (2006.01) A61K 47/12 (2006.01)
Patent
CA 2171435
The effervescent granulated material for a pharmaceutical preparation contains calcium carbonate and citric acid, where 5 to 20 parts by weight of the total acid provided for the reaction with the calcium carbonate are replaced by at least one of the following compounds: malic acid, gluconic acid and lactic acid as well as their (preferably acid) salts. Citric acid and calcium carbonate are granulated with an attendant partial reaction, and in each case at least a part of the compound partially replacing the citric acid is granulated in solid, powdered form together with the citric acid and the calcium carbonate and/or dissolved in granulation liquid or buffer solution.
L'invention concerne un granulat effervescent utilisé pour produire une préparation pharmaceutique, qui contient du carbonate de calcium et de l'acide citrique, 5 à 20 parties en poids du volume total de l'acide prévu pour effectuer la réaction avec le carbonate de calcium étant remplacées par au moins un des composés suivants: acide malique, acide gluconique et acide lactique, ainsi que leurs sels, de préférence acides. L'acide citrique et le carbonate de calcium sont granulés avec une amorce partielle de réaction et au moins une partie du composé qui remplace partiellement l'acide citrique est granulée sous forme solide pulvérisée, conjointement avec l'acide citrique et le carbonate de calcium et /ou est dissoute dans le liquide de granulation ou la solution tampon.
Gergely Gerhard
Gergely Irmgard
Gergely Stefan
Gergely Thomas
Gergely Gerhard
Marks & Clerk
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