A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 9/20 (2006.01) A61K 9/14 (2006.01) A61K 9/46 (2006.01) A61K 31/00 (2006.01) A61K 31/341 (2006.01) A61K 31/4164 (2006.01) A61K 31/426 (2006.01)
Patent
CA 2394902
A histamine H2 antagonist incompatible with acidic materials is incorporated in an effervescent composition and is stable therein provided the acidulant employed in the effervescent couple is a non-hydroxy group containing acidulant and such acidulant is employed as substantially the entire amount of the acidulant present in the formulation. Preferably the composition is devoid of hydroxy group containing acidulant. Adipic acid, succinic acid, fumaric acid and succinic anhydride may be employed as the acidulant. Adipic acid is preferred.
L'invention concerne des antagonistes d'histamine H2 incompatibles avec des matériaux acides incorporés dans une composition effervescente, ces antagonistes étant stables dans ladite composition. Un agent acidifiant utilisé dans le couple effervescent est un groupe non hydroxy, et ledit agent acidifiant représente sensiblement la quantité totale d'agent présent dans la formulation. Cette composition est, de préférence, dépourvue de groupe hydroxy renfermant un agent acidifiant. Il est possible d'utiliser l'acide adipique, l'acide succinique, l'acide fumarique et l'anhydride succinique comme agent acidifiant, l'acide adipique étant l'acide préféré.
Hussein M. Mamoun
Migton John
Bristol-Myers Squibb Company
Gowling Lafleur Henderson Llp
Novartis Ag
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