C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 5/09 (2010.01) C12N 5/078 (2010.01) G01N 33/543 (2006.01) G01N 33/554 (2006.01) G01N 33/574 (2006.01)
Patent
CA 2229001
Tumor cells, particularly carcinoma cells, are separated from peripheral blood by magnetic sorting. The tumor cells are magnetically labeled with antibodies directed to tissue specific antigens, preferably cytoplasmic proteins. Labeling for cytoplasmic antigens is accomplished first permeabilizing, then fixing the cells. The cells are separated on a magnetic matrix. The number of tumor cells in the enriched fraction is used to calculate the number of tumor cells present in a patient hematopoietic sample.
On peut séparer par tri magnétique les cellules tumorales d'avec le sang périphérique, et notamment les cellules de carcinomes. Les cellules tumorales sont marquées magnétiquement par des anticorps dirigés vers des antigènes spécifiques de tissus, de préférence des protéines cytoplasmiques. Le marquage des antigènes cytoplasmiques se fait par perméabilisation, puis fixation des cellules dont la séparation s'effectue sur une matrice magnétique. Le nombre des cellules tumorales de la fraction enrichie sert à calculer celui des cellules tumorales présentes dans un échantillon hématopoïétique prélevé sur un patient.
Kantor Aaron
Miltenyi Stefan
Qian Fawn
Schmitz Jurgen
Amcell Corporation
Miltenyi Biotech Gmbh
Smart & Biggar
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