C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 233/54 (2006.01) C07D 233/38 (2006.01) C07D 233/66 (2006.01) C07D 521/00 (2006.01)
Patent
CA 2417426
The present invention provides of method of preparing phenyl-substituted azoles. This method uses an efficient ligand-accelerated Ullmann coupling reaction of anilines with azoles. The coupling products are useful for preparing factor Xa inhibitors.
La présente invention concerne l'élaboration d'azoles à substitution phénylique. Ce procédé fait usage d'une réaction de couplage d'Ullmann accélérée par les ligands entre les anilines et les azoles. Ces produits de couplage conviennent à l'élaboration d'inhibiteurs du facteur Xa.
Clark Charles G.
Confalone Pasquale N.
Li Hui-Yin
Oh Lynette M.
Rossano Lucius T.
Bristol-Myers Squibb Pharma Company
Gowling Lafleur Henderson Llp
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