Efficient production of heterologous proteins using mannosyl...

Details Efficient production of heterologous proteins using mannosyl... Efficient production of heterologous proteins using mannosyl...

C - Chemistry, Metallurgy

07

D

C07D 277/36 (2006.01) C12P 21/02 (2006.01)

Patent

CA 2721459

Compounds and methods are described for producing protein compositions having reduced amounts of O-linked glycosylation. The method includes producing the protein in cells cultured in the presence of certain benzylidene thiazolidinediones inhibitors of Pmt-mediated O-linked glycosylation.

L'invention porte sur des composés et sur des procédés de production de compositions de protéine renfermant des quantités réduites de glycosylation à liaison O. Le procédé consiste à produire de la protéine dans des cellules cultivées en présence de certains inhibiteurs de benzylidène thiazolidinediones de glycosylation à liaison O à médiation par Pmt.

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