Efflux pump inhibitors

Details Efflux pump inhibitors Efflux pump inhibitors

A - Human Necessities

61

K

A61K 38/05 (2006.01) A61K 31/00 (2006.01) A61K 31/167 (2006.01) A61K 31/18 (2006.01) A61K 38/14 (2006.01) C12Q 1/18 (2006.01)

Patent

CA 2217865

Methods are provided for screening for inhibitors of microbial efflux pumps, including those which export antibiotics. The screening methods are based on the increase in the intracellular concentration of a compound, such as an antibiotic or a dye, when the bacterial cells are contacted with an efflux pump inhibitor. In addition, this invention provides pharmaceutical compositions containing such efflux pump inhibitors, and methods for treating microbial infections using those compositions.

L'invention se rapporte à des procédés de criblage d'inhibiteurs de pompes à écoulement microbien, y compris celles exportant des antibiotiques. Ces procédés de criblage sont basés sur l'augmentation de la concentration intracellulaire d'un composé, tel qu'un antibiotique ou un colorant, lorsque les cellules bactériennes sont mises en contact avec un inhibiteur de pompe à écoulement. Cette invention se rapporte en outre à des compositions pharmaceutiques contenant ces inhibiteurs de pompe à écoulement ainsi qu'à des procédés de traitement d'infections microbiennes dans lesquels ces compositions sont utilisées.

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