Egf-like factor from chromaffin granules and glia...

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/18 (2006.01) A61K 38/18 (2006.01) C07K 14/475 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2262884

The present invention relates to chromaffin granule-derived EGF-like proteins that are involved in promoting survival of DAergic neurons, to nucleotide sequences encoding said proteins or a functionally active derivative or part thereof, and to processes for their preparation. The present invention relates further on to glia cell-derived neurotrophic factors that are capable of promoting survival of DAergic neurons, to nucleotide sequences encoding said factors or a functionally active derivative or part thereof, and to a process for their preparation.

L'invention concerne des protéines semblables à EGF dérivées de granules de chromaffine présentant une activité favorisant la survie de neurones DAergiques, des séquences de nucléotides codant lesdites protéines ou un de leurs dérivés ou une de leurs parties présentant une activité fonctionnelle, ainsi que des procédés servant à les préparer. Elle concerne également des facteurs neurotrophiques dérivés de cellules glia, capables de favoriser la survie de neurones DAergiques, des séquences de nucléotides codant lesdits facteurs ou un de leurs dérivés ou une de leurs parties présentant une activité fonctionnelle, ainsi qu'un procédé servant à les préparer.

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