Egf variants and pharmaceutical use thereof

Details Egf variants and pharmaceutical use thereof Egf variants and pharmaceutical use thereof

C - Chemistry, Metallurgy

12

N

530/7.1, 195/1.3

C12N 15/18 (2006.01) A61K 38/18 (2006.01) C07K 14/485 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2011008

Biologically active variants of epidermal growth factor are provided, comprising tandemly linked units of monomeric EGF. The variants are used per se as therapeutic agents. Production of the multimeric EGF by genetically engineered microbial hosts is also described.

ariantes biologiquement actives du facteur de croissance épidermique (FCE) comprenant des unités de FCE monomérique liées en tandem. Les variantes sont utilisées en soi comme agents thérapeutiques. Est décrite aussi la production de FCE multimérique par des hôtes microbiens génétiquement modifiés.

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