Egfr dependent modulation of chemokine expression and...

G - Physics – 01 – N

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G01N 33/50 (2006.01) G01N 33/574 (2006.01)

Patent

CA 2625291

The invention relates to diagnosis and therapy of tumors utilizinging the epidermal growth factor (EGFR) by means of chemical inhibitors or monoclonal antibodies. The invention relates also to skin irritations, preferably skin rash, in conjunction and associated with the treatment of tumor cells that utilize EGF receptor with anti-cancer agents. The invention is also directed to methods of predicting the efficiency of a tumor therapy / tumor response in a patient based on the treatment with EGFR inhibitors, especially anti-EGFR antibodies. The invention further relates to a method of determining the optimum dose of an anti- cancer agent in EGFR related tumor therapy.

La présente invention concerne le diagnostic et le traitement des tumeurs induites par le récepteur du facteur de croissance épidermique (Epidermal Growth Factor Receptor ; EGFR) au moyen d'inhibiteurs chimiques ou d'anticorps monoclonaux. L'invention concerne également les irritations cutanées, en particulier les toxidermies, conjointes et associées au traitement par des agents anticancéreux des cellules des tumeurs induites par le récepteur des EGF. L'invention concerne aussi des procédés destinés à prédire l'efficacité chez un patient du traitement d'une tumeur par des inhibiteurs de l'EGFR, en particulier par des anticorps anti-EGFR, et la réponse de la tumeur. L'invention concerne en outre un procédé destiné à déterminer la dose optimale d'un agent anticancéreux dans le traitement d'une tumeur liée à l'EGFR.

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