Egfr-homing double-stranded rna vector for systemic cancer...

Details Egfr-homing double-stranded rna vector for systemic cancer... Egfr-homing double-stranded rna vector for systemic cancer...

C - Chemistry, Metallurgy

12

N

C12N 15/117 (2010.01) A61K 47/48 (2006.01) A61P 35/00 (2006.01) A61P 37/04 (2006.01) C07K 14/485 (2006.01) C07K 14/71 (2006.01)

Patent

CA 2748125

An epidermal growth factor receptor (EGFR)-homing vector comprising a double- stranded RNA (dsRNA) molecule with an EGFR-binding peptide or polypeptide, is disclosed for use in combination with immune cells for treatment of cancer overexpressing EGFR

L'invention concerne un vecteur ciblant le récepteur de facteur de croissance épidermique (EGFR) comprenant une molécule d'ARN bicaténaire (ARNds) avec un peptide ou un polypeptide liant EGFR, destiné à être utilisé en combinaison avec des cellules immunitaires pour le traitement d'un cancer associé à une surexpression d'EGFR.

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