Egfr ligands and methods of use

Details Egfr ligands and methods of use Egfr ligands and methods of use

A - Human Necessities

61

K

A61K 39/395 (2006.01) A61K 39/40 (2006.01) A61K 47/48 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2479306

EGFR is over-expressed in malignant gliomas and, when activated, transduces apoptotic signals in these cancer cells. Chimeric molecules that contain an EGFR ligand and a carrier molecule are used to specifically target, and in some cases induce apoptosis in, EGFR-expressing cells.

Pour les besoins de l'invention, sachant que la surexpression du R-EGF survient dans les gliomes malins, et que l'activation du R-EGF entraîne la transduction des signaux apoptotiques dans les cellules cancéreuses correspondantes, on utilise des molécules chimères qui contiennent un ligand du R-EGF et une molécule porteuse afin de cibler spécifiquement les cellules exprimant le R-EGF et, dans certains cas, afin d'induire l'apoptose au sein de ces cellules.

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