Egln2 variants and use thereof in preventing or treating...

Details Egln2 variants and use thereof in preventing or treating... Egln2 variants and use thereof in preventing or treating...

C - Chemistry, Metallurgy

07

K

C07K 14/435 (2006.01) A61P 9/10 (2006.01)

Patent

CA 2625613

The invention relates to human EGLN2-variants having a serine or a leucine in position 58 of the amino acid sequence and to the use thereof in preventing or treating thromboembolic disorders or coronary heart diseases, in particular, cerebral apoplexy, prolonged reversible ischaemic neurological deficit (PRIND), transient ischaemic attack (TIA), myocardial infarct and/or premature myocardial infarct.

L'invention concerne des variantes de l'EGLN2 humaine, comportant une sérine ou une leucine en position 58 de la séquence d'aminoacide, ainsi que leur utilisation dans la prophylaxie ou le traitement de maladies thromboemboliques ou de maladies coronariennes, notamment en cas d'accident vasculaire cérébral, de déficit neurologique ischémique prolongé réservible (PRIND), d'attaque ischémique transitoire, d'infarctus du myocarde et/ou d'infarctus du myocarde précoce.

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