Eif-5a nucleic acids for inhibiting apoptosis

Details Eif-5a nucleic acids for inhibiting apoptosis Eif-5a nucleic acids for inhibiting apoptosis

A - Human Necessities

61

K

A61K 48/00 (2006.01) C07K 14/47 (2006.01)

Patent

CA 2484144

The present invention relates to isolated and/or purified rat apoptosis- specific eucaryotic initiation Factor-5A (eIF-5A) and deoxyhypusine synthase (DHS) nucleic acids and polypeptides. The present invention also relates to methods of modulating apoptosis using apoptosis-specific eIF-5A and DHS, and antisense oligonucleotides and expression vectors of apoptosis-specific eIF-5A and DHS useful in such methods.

L'invention concerne des acides nucléiques isolés et/ou purifiés de déoxyhypusine synthase (DHS) et de facteur-5A (eIF-5A) d'initiation eucaryote spécifique de l'apoptose chez le rat, et des polypeptides. L'invention concerne également des méthodes permettant de moduler une apoptose à l'aide de DHS et du facteur eIF-5A spécifique d'une apoptose, des oligonucléotides antisens et des vecteurs d'expression de DHS et du facteur eIF-5A spécifique d'une apoptose utilisés dans lesdites méthodes.

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