Eif4e regulon-based diagnostics

C - Chemistry – Metallurgy – 07 – K

Patent

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Details

C07K 16/18 (2006.01) C12Q 1/02 (2006.01) C12Q 1/68 (2006.01) C40B 30/02 (2006.01) C40B 30/04 (2006.01) G01N 33/53 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2664712

Provided are methods and compositions for the identification, diagnosis and monitoring of 4E regulon activity and for the discovery of agents that modulate 4E regulon activity. The methods, compositions and agents may be used alone, in combination with or in conjunction with other therapies for the detection and treatment of diseases wherein 4E regulon activity is dysfunctional, including cellular hypertrophy, cancer, and ischemia reperfusion.

L'invention concerne des procédés et des compositions pour l'identification, le diagnostic et la surveillance d'une activité de régulon 4E, et la découverte d'agents qui modulent l'activité du régulon 4E. Les procédés, compositions et agents peuvent être utilisés seuls, en combinaison avec ou en association avec d'autres thérapies pour la détection et le traitement de maladies où l'activité du régulon 4E est dysfonctionnelle, y compris une hypertrophie cellulaire, le cancer et une reperfusion d'ischémie.

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