A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/39 (2006.01) A61F 2/00 (2006.01) A61L 31/04 (2006.01) A61P 9/10 (2006.01) C07K 14/78 (2006.01) G01N 33/50 (2006.01)
Patent
CA 2362548
The present invention provides screening methods that use organisms or cells that lack function in one or both elastin genes. These methods are useful in identifying drugs for the prevention and treatment of obstructive vascular diseases, such as atherosclerosis, vascular restenosis and transplant arteriopathy. Further, the invention provides pharmaceutical compositions containing elastin-based compositions that are particularly potent regulators of proliferation, differentiation, and migration of smooth muscle cells in vitro and in vivo. These pharmaceutical compositions and related methods are useful in the prevention and treatment of disorders characterized by diminished capacity to regulate smooth muscle cell function.
L'invention concerne des procédés de criblage utilisant des organismes ou des cellules privés de fonction dans l'un ou les deux gènes de l'élastine et servant à identifier des médicaments pour la prévention et le traitement de maladies vasculaires obstructives, telles que l'athérosclérose, la resténose vasculaire et l'artériopathie de greffe. L'invention concerne également des compositions pharmaceutiques contenant des compositions à base d'élastine qui sont des régulateurs particulièrement efficaces de la prolifération, la différenciation et la migration de cellules des muscles lisses in vitro et in vivo. Ces compositions pharmaceutiques et les procédés apparentés conviennent particulièrement à la prévention et au traitement de troubles caractérisés par une diminution de la capacité à réguler la fonction des cellules des muscles lisses.
Keating Mark T.
Li Dean Y.
Fetherstonhaugh & Co.
University Of Utah Research Foundation
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