A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/39 (2006.01) A61K 31/353 (2006.01) A61K 31/366 (2006.01) A61K 31/7048 (2006.01)
Patent
CA 2608747
The present invention describes therapeutic compositions comprising fibroblasts that have been stimulated to increase expression of extracellular matrix components or elastin, or to produce enhanced elastogenesis or the appearance thereof at a site of administration. The therapeutic fibroblast formulations can be prepared using a variety of elastogenic agents, including digests of mammalian elastin, chemically digested plant extracts comprising elastin-like peptides, and synthetic elastogenic peptides. The invention further comprises cosmetic and pharmaceutical treatment methods using the therapeutic fibroblast compositions of the invention.
L'invention concerne des compositions thérapeutiques qui comprennent des fibroblastes ayant été stimulés en vue d'accroître l'expression de composants de la matrice extracellulaire ou de l'élastine, de produire une élastogenèse accrue ou d'amorcer une élastogenèse sur le site d'administration. Les formulations thérapeutiques de fibroblastes peuvent être préparées à l'aide de divers agents élastogènes, y compris des produits de la digestion d'élastine de mammifère, des extraits de plantes digérées chimiquement comprenant des peptides du type élastine, et des peptides élastogènes de synthèse. L'invention concerne de plus des méthodes de traitement cosmétique et pharmaceutique utilisant ces compositions thérapeutiques de fibroblastes.
Hinek Aleksander
Jimenez Felipe
Mitts Thomas F.
Borden Ladner Gervais Llp
Human Matrix Sciences Llc
The Hospital For Sick Children
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