C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/02 (2006.01) C12M 3/00 (2006.01) C12Q 1/04 (2006.01) G01N 27/26 (2006.01) G01N 27/416 (2006.01) G01N 33/15 (2006.01) G01N 33/50 (2006.01) G01N 33/68 (2006.01)
Patent
CA 2453489
Methods of identifying activators and inhibitors of voltage-gated ion channels are provided in which the methods employ electrical field stimulation of the cells in order to manipulate the open/close state transition of the voltage- gated ion channels. This allows for more convenient, more precise experimental manipulation of these transitions, and, coupled with efficient methods of detecting the result of ion flux through the channels, provides methods that are especially suitable for high throughput screening.
Cette invention se rapporte à des procédés qui servent à identifier des activateurs et des inhibiteurs des canaux ioniques potentio-dépendants et qui utilisent à cet effet la stimulation du champ électrique des cellules, afin de manipuler la transition entre l'état ouvert et fermé de ces canaux ioniques potentio-dépendants. Ces procédés permettent une manipulation expérimentale plus commode et plus précise de ces transitions et, lorsqu'ils sont associées à des procédés efficaces de détection du résultat du flux ionique à travers ces canaux, ils offrent des techniques particulièrement appropriées pour des opérations de criblage de grand rendement.
Augustine Paul R.
Bennett Paul B.
Bugianesi Randal M.
Garyantes Tina A.
Imredy John P.
Merck & Co. Inc.
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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