Electro-release systems, modified electrodes and their use

A - Human Necessities – 61 – N

Patent

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A61N 1/30 (2006.01) A61K 9/00 (2006.01) A61N 1/04 (2006.01)

Patent

CA 2278814

An electro-release system, for example for use in releasing a pharmaceutical compound, has an electrode and a layer structure on said electrode releasably holding an electro-releasable compound. The layer structure comprises at least one functional compound providing a first functional group forming an ionic bond with the electro- releasable compound and a second functional group which, on application of an appropriate voltage bias to the electrode, generates protons which break the ionic bond, thereby controlling release of the electro-releasable compound. Also disclosed are modified electrodes useful in such an electro-release system and having polymer bilayers based on polypyrrole or polythiophene with the two layers carrying different substituents giving different functionality or reactivity.

La présente invention concerne un système d'électro-libération, destiné par exemple à libérer un composé pharmaceutique, comprenant une électrode et, sur cette électrode, une structure de couche retenant de façon libérable un composé électro-libérable. La structure de couche comprend au moins un composé fonctionnel constitué d'un premier groupe fonctionnel formant une liaison ionique avec le composé électro-libérable et d'un deuxième groupe fonctionnel qui, lorsqu'une polarisation de tension appropriée est appliquée à l'électrode, émet des protons qui rompent la liaison ionique et commandent de la sorte la libération du composé électro-libérable. L'invention se rapporte également à des électrodes modifiées utilisées dans ce système d'électro-libération et comportant deux couches polymères à base de polypyrrole ou de polythiophène, les deux couches portant des substituants différents qui leur confèrent des fonctionnalités et des réactivités différentes.

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