Electrochemical assay for cis-diols

Details Electrochemical assay for cis-diols Electrochemical assay for cis-diols

G - Physics

01

N

150/11, 324/23

G01N 33/72 (2006.01) C12Q 1/00 (2006.01) C12Q 1/26 (2006.01) G01N 33/487 (2006.01) G01N 33/66 (2006.01)

Patent

CA 1244882

ABSTRACT ELECTROCHEMICAL ASSAY FOR CIS-DIOLS The invention disclosed relates to an electrochemical assay which is particularly concerned with an assay for the presence of, or amount of, glycosylated haemoglobin in a blood sample, but which extends a general assay for detecting the presence of, monitoring the level of or determining the concentration of compounds containing cis-diol groups, such as glycols, nucleic acid components, sugars, polyols, catechols and glycosylated proteins. When ferrocene boronic acid or a derivative thereof is present free in solution, it can act as a mediator for a wide range of oxido-reductases. However in the presence of, for example, sugars containing the cis-diol structure, the metallocine (such as ferrocene boronic acid) covalently binds to the sugar. When the ferrocene boronic acid is thus bound, it is essentially immobilized and its properties as a mediator and abillity to diffuse will be markedly affected. Refer to figure 1

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