Electrochemical sensing apparatus with in situ calibration...

Details Electrochemical sensing apparatus with in situ calibration... Electrochemical sensing apparatus with in situ calibration...

G - Physics

01

N

324/3

G01N 27/26 (2006.01) A61B 5/00 (2006.01) G01N 27/28 (2006.01) G01N 27/416 (2006.01) G01N 37/00 (2006.01)

Patent

CA 1155316

ABSTRACT OF THE DISCLOSURE An in vivo electrochemical monitoring device is formed by a catheter-like member which terminates in a closed end having a wall with a fixed opening to admit fluid to be tested, such as blood in an artery. An electrochemical sensor, such as an ion sensitive field effect transistor (ISFET) device for monitoring the con- centration of a particular ion in blood, is mounted inside the tube at a fixed location below the opening preferably a larger sensing chamber. An infusion channel in the tube is arranged to flood the sensor with a fluid of known chemical properties so that the sensor output can be calibrated. Under pressure the calibration fluid expels the test fluid out of the tube or chamber via the fixed opening. A method of con- structing a suitable chamber on an ISFET wafer is also disclosed.

372600

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