Electrochemical sensing cell with in situ calibration

G - Physics – 01 – N

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G01N 27/30 (2006.01) G01N 33/50 (2006.01)

Patent

CA 1173109

ABSTRACT OF THE DISCLOSURE An electrochemical sensing cell for use with an in vivo electrochemical monitoring device. The device has a catheter-like member which terminates in a closed end having a wall with a fixed opening to admit fluid to be tested, such as blood in an artery. The sensing cell includes an ion sensitive field effect transistor (ISFET) device for monitoring the concentration of a particular ion in blood and is mounted inside the tube at a fixed location below the opening preferably a larger sensing chamber. An infusion channel in the tube is arranged to flood the sensor with a fluid of known chemical properties so that the sensor output can be calibrated. Under pressure the calibration fluid expels the test fluid out of the tube or chamber via the fixed opening.

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