Electrogenic pump molecule control

A - Human Necessities – 61 – N

Patent

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A61N 1/32 (2006.01) A61N 1/00 (2006.01) C12M 1/42 (2006.01) C12N 9/14 (2006.01) C12N 13/00 (2006.01)

Patent

CA 2644129

Activation of electrogenic pump molecules can be realized by a dynamic entrainment procedure which includes two steps: synchronization of individual pump molecules to work at the same pumping pace, and gradual modulation of the synchronization frequency. We studied synchronization of the Na/K pump molecules in a physiological running mode by applying the concept of an electronic synchrotron to the biological system. Both theoretical analysis and experimental results showed that individual Na/K pump molecules can be synchronized by a well designed oscillating electric field. The synchronized pump currents show separated inward and outward pump currents and a magnitude ratio of 3:2 reflecting stoichiomatric number of the pump molecules.

L'invention concerne l'activation de molécules de transport électrogenic réalisée par une procédure d'entraînement dynamique comprenant deux étapes : la synchronisation de molécules de transport individuelles pour fonctionner au même rythme de pompage et la modulation progressive de la fréquence de synchronisation. Nous avons étudié la synchronisation des molécules de transport Na/K dans un mode de fonctionnement physiologique en appliquant le concept d'un synchrotron électronique au système biologique. L'analyse théorique comme les résultats expérimentaux ont montré que des molécules de transport Na/K individuelles pouvaient être synchronisées par un champ électrique oscillant conçu de façon adéquate. Les courants de transport synchronisés font apparaître des courants de transport entrants et sortants séparés et un rapport d'amplitude de 3:2 reflétant le nombre stAEchiométrique des molécules de transport.

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