Electrolyte solutions and in vivo use thereof

Details Electrolyte solutions and in vivo use thereof Electrolyte solutions and in vivo use thereof

A - Human Necessities

61

K

167/256

A61K 31/70 (2006.01) A61K 31/56 (2006.01) A61K 31/65 (2006.01) A61K 31/66 (2006.01) A61K 33/00 (2006.01) A61M 1/16 (2006.01)

Patent

CA 1264442

ABSTRACT Electrolyte solutions are provided which are useful in electrolyte and fluid therapy, parenteral nutrition, and dialysis. The Na:Cl ratio is normalized, plasma and cellullar pH are normalized, and cellular cofactor ratios are normalized, in a manner which decreases toxicity over prior art solutions. The solutions employ at least one of the following near-equilibrium couples: (a) bicarbonate/CO2; (b) 1-lactate/pyruvate; and (c) d- betahydroxybutyrate/ acetoacetate.

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