Electrolytic transdermal delivery of polypeptides

Details Electrolytic transdermal delivery of polypeptides Electrolytic transdermal delivery of polypeptides

A - Human Necessities

61

N

128/104, 167/159

A61N 1/30 (2006.01) A61K 9/00 (2006.01) A61M 37/00 (2006.01)

Patent

CA 1317879

ABSTRACT The invention comprises in combination: a) a polypeptide having from about three to about 20 peptide units in aqueous solution or suspension, and b) an electrolytic device for transdermal transport of the polypeptide to the bloodstream of the patient. It may be useful to enhance the transdermal delivery of the polypeptide by adding an aqueous cosolute/cosolvent with negative Setschenow constants. The electrolytic device preferably comprises a hydrophilic reservoir containing a supply of the aqueous polypeptide solution or suspension, an electric battery, two extended contacts, and optionally a semipermeable membrane between the reservoir and the patients skin. Representative polypeptides include oxytocin, angiotensin I, II, and III, substance P, vasopressin, lypressin, desmopressin, leuprolide acetate, antripeptin, and the like.

558558

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