Electrolytic transdermal delivery of proteins

Details Electrolytic transdermal delivery of proteins Electrolytic transdermal delivery of proteins

A - Human Necessities

61

N

167/103, 167/159

A61N 1/30 (2006.01) A61K 9/00 (2006.01)

Patent

CA 1319608

ABSTRACT A chemical composition for electrolytic transdermal transport. of a protein to the blood stream of the patient comprises: a) a protein, b) a cosolvent with negative Setschenow constants, and c) water. Some of the preferred proteins are: insulin, protamine sulfate, calcitonin, glucagon, and corticotropin. Some of the preferred dissociating agents with negative Setschenow constants are: urea, propylurea, potassium iodide, sodium perchlorate, and guanidine hydrochloride. The electrolytic device containing the composition to be transdermally delivered comprises: two electrode elements separated by barrier means, a reservoir containing the composition of the invention, an electronic/electrolytic circuit including a source of a power, a cover, and adhesive means holding the device to the patient's skin. A semipermeable membrane between the patient's skin and the electrolytic device is optional.

558559

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