Electrophoresis with chemically suppressed detection

Details Electrophoresis with chemically suppressed detection Electrophoresis with chemically suppressed detection

G - Physics

01

N

G01N 27/447 (2006.01) G01N 30/60 (2006.01)

Patent

CA 2096823

Improved capillary electrophoresis apparatus of the type that generally includes a capillary tube, the capillary tube having a sample inlet end and an outlet end, a first electrode in electrical communication with the inlet end of the capillary tube, a sec- ond electrode in electrical communication with the outlet end of the capillary tube and a high voltage power supply in electrical communication with the first and second electrodes. The improvement is to connect a miniature Ion Chromatography membrane suppressor to the outlet end of the capillary tube, to connect a conductivity detector to the membrane suppressor and to place the second electrode in the regenerant compartment of the membrane suppressor. The method embodiment of the invention for anion analysis includes the steps of: (a) separating anions of interest by capillary electrophoresis in a buffer solution; (b) exchanging cations of the buffer for regenerant cations using an ion chromatography membrane suppressor to reduce the electrical conductiv- ity of the buffer to produce a suppressed buffer; and (c) measuring the electrical conductivity of the suppressed buffer to deter- mine the separated anions. Similarly, the method embodiment of the invention for cation analysis includes the steps of: (a) sepa- rating cations of interest by capillary electrophoresis in a buffer solution; (b) exchanging anions of the buffer for regenerant anions using a stationary means for exchanging anions thereby reducing the electrical conductivity of the buffer to produce a sup- pressed buffer; and (c) measuring the electrical conductivity of the suppressed buffer to determine the separated cations.

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