Electrophoretic tag-based in vitro assay to quantify...

Details Electrophoretic tag-based in vitro assay to quantify... Electrophoretic tag-based in vitro assay to quantify...

G - Physics

01

N

G01N 33/573 (2006.01) G01N 33/58 (2006.01)

Patent

CA 2690635

Methods for measuring hetero- and homodimerization of HIV reverse transcriptase (HIV RT) are provided using pairs of tagged probes and cleaving probes. The methods can be used, for example, to screen for modulators of HIV RT dimerization. Also provided are methods of determining whether a compound modulates HIV RT. Further provided are methods of determining whether a compound modulates formation of a complex between a p66 and p51, p66 and p66, or p51 and p55 subunits polypeptides of HIV RT.

L'invention porte sur des procédés pour mesurer une hétéro- et homodimérisation de la transcriptase inverse du VIH (RT du VIH), lesquels sont fournis à l'aide de paires de sondes marquées et de sondes de clivage. Les procédés peuvent être utilisés, par exemple, pour cribler des modulateurs d'une dimérisation de la RT du VIH. L'invention porte également sur des procédés de détermination du point de savoir si un composé module la RT du VIH. L'invention porte en outre sur des procédés pour déterminer si ou non un composé module la formation d'un complexe entre des polypeptides de sous-unités p66 et p51, p66 et p66 ou p51 et p55 de la RT du VIH.

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