Electroprocessed fibrin-based matrices and tissues

D - Textiles – Paper – 04 – H

Patent

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Details

D04H 1/728 (2012.01) C12N 5/07 (2010.01) A61K 47/42 (2006.01) A61L 15/32 (2006.01) A61L 27/38 (2006.01) A61L 27/40 (2006.01) A61L 31/12 (2006.01) C07K 14/75 (2006.01) C07K 14/78 (2006.01) C12N 11/02 (2006.01) A61K 35/12 (2006.01)

Patent

CA 2457162

The invention is directed to formation and use of electroprocessed fibrin as an extracellular matrix and, together with cells, its use in forming engineered tissue. The engineered tissue can include the synthetic manufacture of specific organs or tissues which may be implanted into a recipient. The electroprocessed fibrin may also be combined with other molecules in order to deliver the molecules to the site of application or implantation of the electroprocessed fibrin. The fibrin or fibrin/cell suspension is electrodeposited onto a substrate to form the tissues and organs.

L'invention concerne la formation et l'utilisation d'une matrice extracellulaire et, en conjonction avec les cellules, son utilisation dans la formation de tissus d'ingénierie. Le tissu d'ingénierie peut comprendre la fabrication synthétique d'organes ou de tissus déterminés qui peuvent être implantés chez un récipient. La fibrine ayant subi un traitement électrique peut aussi être combinée à d'autres molécules afin d'acheminer ces molécules jusqu'au site d'application ou d'implantation de la fibrine traitée électriquement. La suspension de fibrine ou de fibrine / cellules est déposée électriquement sur le substrat pour former les tissus et organes.

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