Electrorotation

Details Electrorotation Electrorotation

G - Physics

01

N

G01N 33/543 (2006.01) C12Q 1/68 (2006.01) C40B 30/00 (2006.01) C40B 70/00 (2006.01) G01N 33/53 (2006.01) G01N 33/58 (2006.01)

Patent

CA 2129729

A method of analysis comprises forming complexes between micro-particles (12) such as plastics beads, a linking moiety (14) such as an antibody attached to the micro-particle, and a target (16) such as a micro-organism and observing the electro-rota-tion properties of the complex (10). Electro-rotation is produced by applying a rotating electric field in a plane transverse to the direction of observation. The differing electro-rotation properties of the micro-particles (12) coated with antibody (14) alone and the complexes (10) are visually observable and in suitable cases discrimination is possible between complexes containing live tar-get micro-organisms and those containing dead micro-organisms. The target (16) may be bound to a labelling moiety (14) such as a gold or magnetic particle to enhance change in electro-rotation properties produced on complex formation. A wide range of tar-get species are detectable, including nucleic acids and proteins.

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