Electrostatically depositing a medicament powder

A - Human Necessities – 61 – J

Patent

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Details

A61J 3/02 (2006.01) A61J 3/00 (2006.01) A61M 15/00 (2006.01) B05B 5/025 (2006.01) B05B 5/047 (2006.01) G03G 15/22 (2006.01) G03G 15/32 (2006.01) A61M 15/02 (2006.01)

Patent

CA 2223251

Apparatus and a method for electrostatically depositing doses of medicament powder (304) at selected locations on a substrate (110), such as those that are used to fabricate suppositories, inhalants (704), tablets, and capsules. The apparatus contains a charged particle emitter (102) for generating charged particles that charge a predefined region of a substrate (500) and a charge accumulation control circuit (108) for computing the amount of charge accumulated upon the substrate (500) and deactivating the emitter (102) when a selected quantity of charge has accumulated. A triboelectric charging apparatus (302) charges the medicament powder (304) and forms a charged medicament cloud (412) proximate the charged region of the substrate (500). The medicament particles within the medicament cloud (412) electrostatically adhere to the charged region. The quantity of charge accumulated on the substrate (500) at the predefined region and the charge-to-mass ratio of the medicament powder (304) in the cloud (412) control the dose of medicament deposited and retained by the substrate (500).

L'invention concerne un appareil et un procédé permettant le dépôt électrostatique de doses d'un médicament pulvérulent (304) en des endroits choisis sur un susbtrat (110) du type de ceux qui sont utilisés pour fabriquer des suppositoires, des produits pour inhalation (704), des comprimés et des gélules. L'appareil contient un émetteur (102) de particules chargées destiné à produire des particules chargées qui chargent une région prédéfinie d'un substrat (500), et un circuit de commande (108) d'accumulation de charge permettant de calculer la quantité de charge accumulée sur le substrat (500) et de désactiver l'émetteur (102) après accumulation d'une quantité sélectionnée de charge. Un chargeur triboélectrique (302) charge le médicament pulvérulent (304) et forme un nuage de médicament chargé (412) à proximité de la région chargée du substrat (500). Les particules médicamenteuses au sein du nuage (412) adhèrent par voie électrostatique à la région chargée. La quantité de charge accumulée sur le substrat (500) au niveau de la région prédéfinie et le rapport charge/masse du médicament pulvérulent (304) dans le nuage (412) déterminent la dose de médicament déposée et retenue par le substrat (500).

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