Eliciting hcv-specific antibodies

A - Human Necessities – 61 – K

Patent

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A61K 39/29 (2006.01) A61K 9/00 (2006.01) A61K 31/7088 (2006.01) A61K 39/39 (2006.01) C07K 14/18 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2393251

Described herein is a method of eliciting antibodies and neutralizing of binding antibodies against a hepatitis C virus (HCV) E1E2 or E2 antigen using HCV E2 or HCV E1E2 polypeptides and/or HCV E2 or E1E2 polynucleotides. Elicitation of anti-E2 antibodies and anti-E2 NOB antibodies can be used, inter alia, to provide model systems to optimize anti-E2 antibody responses and/or anti-E2 NOB antibody responses to HCV and to provide prophylactic or therapeutic treatment against HCV infection.

L'invention concerne un procédé permettant d'éliciter des anticorps et de neutraliser des anticorps de fixation contre des antigènes E1E2 ou E2 du virus de l'hépatite C (VHC) au moyen de polypetides VHC E2 ou VHC E1E2 et/ou de polynucléotides VHC E2 ou E1E2. L'élicitation d'anticorps anti-E2 et d'anticorps anti-E2 de neutralisation de fixation peut être utilisée, entre autres, afin de fournir des systèmes de modèles destinés à optimiser des réponses d'anticorps anti-E2 et/ou des réponses d'anticorps anti-E2 de neutralisation de fixation au VHC et à fournir un traitement prophylactique ou thérapeutique contre une infection du VHC.

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