A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/4166 (2006.01) A61P 39/06 (2006.01)
Patent
CA 2193551
An object of the present invention is to offer a novel agent for eliminating the free radicals and the active oxygen which can be easily made into pharmaceutical preparations, shows little side effects and is capable of being administered by oral route. The agent for eliminating the active oxygen and the free radicals in accordance with the present invention contains a hydantoin derivative represented by the following formula (I). (see formula I) wherein each of R1 and R2, which may be the same or different, represents hydrogen, an alkyl group or a cycloalkyl group; and each of X and Y, which may be the same or different, represents hydrogen, hydroxyl group, an alkyl group or an alkoxy group, or X and Y together represent an oxo group. The above mentioned hydantoin derivative has an action of eliminating the active oxygen and the free radicals. Accordingly, it is useful as a pharmaceutical agent for treating a variety of diseases in which active oxygen and free radicals are participated such as myocardial infarction, reperfusion disturbance, autoimmune diseases, fibrosis, pulmonary diseases, dermatological diseases, arthropathy, side effects of anticancer agents, radiation diseases, septic shock, inflammatory diseases and cataract.
Endou Hitoshi
Ienaga Kazuharu
Kirby Eades Gale Baker
Nippon Zoki Pharmaceutical Co. Ltd.
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