Elimination of endogenous porcine retrovirus

Details Elimination of endogenous porcine retrovirus Elimination of endogenous porcine retrovirus

C - Chemistry, Metallurgy

12

Q

C12Q 1/70 (2006.01) C07H 21/00 (2006.01) C07H 21/02 (2006.01) C07H 21/04 (2006.01) C07K 14/15 (2006.01) C08B 3/00 (2006.01) C08B 37/04 (2006.01) C12N 15/00 (2006.01) C12P 19/34 (2006.01)

Patent

CA 2442819

Porcine nucleic acid sequences flanking potentially infectious porcine endogenous retroviral (PERV) insertion sites have been identified and isolated. The unique flanking sequences include porcine nucleic acid sequences that flank the 3' end and porcine nucleic acid sequences that flank the 5' end of PERV insertion sites. The present invention provides compositions and methods for detecting presence of PERV in a sample, particularly those with infectious potential. In addition, the invention relates to breeding of pigs or selection of porcine tissue that is free of infectious PERV for use as a xenotransplant tissue.

On a identifié et isolé des séquences d'acides nucléiques de porc qui se situent sur le côté de sites d'insertion du rétrovirus porcin endogène (PERV) potentiellement infectieux. Les séquences flanquantes uniques comprennent des séquences d'acides nucléiques qui flanquent l'extrémité 3' et des séquences d'acides nucléiques qui flanquent l'extrémité 5' des sites d'insertion de PERV. Cette invention concerne des compositions et des méthodes qui permettent de détecter la présence de PERV dans un échantillon, plus particulièrement ceux ayant un potentiel infectieux. En outre, cette invention concerne l'élevage porcin ou la sélection de tissus provenant de porcs qui sont dépourvus de PERV infectieux pour utiliser ces derniers en tant que tissus pour des xénotransplants.

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