Elisa kit for the determination of metabolic phenotypes

Details Elisa kit for the determination of metabolic phenotypes Elisa kit for the determination of metabolic phenotypes

G - Physics

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G01N 33/53 (2006.01) C07D 473/08 (2006.01) C07D 473/10 (2006.01) C07D 473/12 (2006.01) G01N 33/543 (2006.01) G01N 33/94 (2006.01)

Patent

CA 2366085

The invention relates to an enzyme linked immunosorbent assay (ELISA) kit for the rapid determination of metabolic phenotypes including but not limited to CYP 1A2, N-acetyltamferase-1 (NAT-1), CYP 2P6, CYP 2E1 and CYP 3A4, which can be used on a routine basis in a clinical laboratory. The ELISA kit allows physicians to a) individualize therapy of drugs such as theophylline, tamoxifen, and clozapine and b) to predict susceptibility to carcinogen induced diseases such as colon rectal cancers. To reduce the number of patients undergoing clinical testing by selecting for patients with the appropriate phenotype most likely to respond.

L'invention concerne un kit de dosage immunoenzymatique (ELISA) pour la détermination rapide de phénotypes métaboliques, comprenant de façon non limitaitive, CYP 1A2, N-acétyltransférase-1 (NAT-1), CYP 2P6, CYP 2E1 et CYP 3A4, pouvant être utilisées sur une base routinière dans un laboratoire clinique. Le kit ELISA permet aux médecins a) de personnaliser la thérapie à la théophylline, au tamoxifène et à la clozapine, et b) de prévoir la vulnérabilité aux maladies induites par les cancérogènes, telles que les cancers du côlon. La réduction du nombre de patients subissant des tests cliniques est également possible par la sélection des patients possédant le phénotype adéquat le plus apte à réagir.

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