Elongase genes and uses thereof

Details Elongase genes and uses thereof Elongase genes and uses thereof

C - Chemistry, Metallurgy

12

N

C12N 15/54 (2006.01) A01H 5/00 (2006.01) A61K 31/23 (2006.01) A61P 3/00 (2006.01) C12N 5/04 (2006.01) C12N 5/10 (2006.01) C12N 9/10 (2006.01) C12N 15/63 (2006.01) C12N 15/82 (2006.01) C12P 7/64 (2006.01) C12P 21/02 (2006.01)

Patent

CA 2487095

The subject invention relates to the identification of several genes involved in the elongation of polyunsaturated acids (i.e., "elongases") and to uses thereof. At least two of these genes are also involved in the elongation of monounsaturated fatty acids. In particular, elongase is utilized in the conversion of gamma linolenic acid (GLA) to dihomogamma linolenic acid (DGLA) and in the conversion of AA to adrenic acid (ADA), or eicosapentaenoic acid (EPA) to .omega.3-docosapentaenoic acid (DPA). DGLA may be utilized in the production of polyunsaturated fatty acids, such as arachidonic acid (AA), docosahexaenoic acid (DHA), EPA, adrenic acid, .omega.6-docosapentaenoic acid or .omega.3-docosapentaenoic acid which may be added to pharmaceutical compositions, nutritional compositions, animal feeds, as well as other products such as cosmetics.

L'invention porte sur l'identification de plusieurs gènes impliqués dans l'élongation d'acides polyinsaturés (appelés les "élongases") et sur leurs utilisations. Au moins deux de ces gènes sont également impliqués dans l'élongation d'acides gras monoinsaturés. L'élongase est notamment utilisée dans la conversion de l'acide gamma linolénique (GLA) en acide dihomogamma linolénique (DGLA) et dans la conversion de AA en acide adrénique (ADA), ou l'acide eicosapentaénoïque (EPA) en acide .omega.3-docosapentaénoïque (DPA). DGLA peut être utilisé dans la production d'acides gras polyinsaturés tels que l'acide arachidonique (AA), l'acide docosahexaénoïque (DHA), EPA, l'acide adrénique, l'acide .omega.6-docosapentaénoïque ou .omega.3-docosapentaénoïque qui peuvent être ajoutés à des compositions pharmaceutiques, des compositions nutritionnelles, des aliments pour animaux de même qu'à d'autres produits tels que des cosmétiques.

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